PDL1 (Imunotherapy) Awọn idanwo

Akoonu

• Kini idanwo PDL1?
• Kini o ti lo fun?
• Kini idi ti Mo nilo idanwo PDL1?
• Kini yoo ṣẹlẹ lakoko idanwo PDL1 kan?
• Ṣe Mo nilo lati ṣe ohunkohun lati mura fun idanwo naa?
• Ṣe eyikeyi awọn eewu si idanwo naa?
• Kini awọn abajade tumọ si?
• Njẹ ohunkohun miiran ti Mo nilo lati mọ nipa idanwo PDL1 kan?
• Awọn itọkasi

Kini idanwo PDL1?

Idanwo yii ṣe iwọn iye PDL1 lori awọn sẹẹli alakan. PDL1 jẹ amuaradagba ti o ṣe iranlọwọ lati jẹ ki awọn sẹẹli alaabo lati kọlu awọn sẹẹli ti ko ni agbara ninu ara. Ni deede, eto aarun ma n ja awọn nkan ajeji bi awọn ọlọjẹ ati kokoro arun, kii ṣe awọn sẹẹli ti ara rẹ. Diẹ ninu awọn sẹẹli alakan ni iye PDL1 giga. Eyi gba awọn sẹẹli akàn laaye lati “tan” eto ara, ati yago fun ikọlu bi ajeji, awọn nkan ti o lewu.

Ti awọn sẹẹli akàn rẹ ba ni iye PDL1 giga, o le ni anfani lati itọju kan ti a pe ni imunotherapy. Immunotherapy jẹ itọju ailera kan ti o ṣe alekun eto alaabo rẹ lati ṣe iranlọwọ fun ọ lati mọ ati ja awọn sẹẹli alakan. Ajẹsara ajẹsara ti han lati munadoko pupọ ni titọju awọn oriṣi awọn aarun kan. O tun duro lati ni awọn ipa ẹgbẹ diẹ ju awọn itọju aarun miiran lọ.

Awọn orukọ miiran: eto-ligand iku 1, PD-LI, PDL-1 nipasẹ imunohistochemistry (IHC)

Kini o ti lo fun?

Ayẹwo PDL1 ni a lo lati wa boya o ni akàn kan ti o le ni anfani lati imunotherapy.

Kini idi ti Mo nilo idanwo PDL1?

O le nilo idanwo PDL1 ti o ba ti ni ayẹwo pẹlu ọkan ninu awọn aarun wọnyi:

• Aarun ẹdọfóró ti kii ṣe kekere
• Melanoma
• Lymphoma Hodgkin
• Aarun àpòòtọ
• Akàn akàn
• Jejere omu

Awọn ipele giga ti PDL1 ni igbagbogbo wa ninu iwọnyi, bii diẹ ninu awọn oriṣi aarun miiran. Awọn aarun ti o ni awọn ipele giga ti PDL1 le ṣe itọju ni igbagbogbo pẹlu imunotherapy.

Kini yoo ṣẹlẹ lakoko idanwo PDL1 kan?

Pupọ awọn idanwo PDL1 ni a ṣe ni ilana ti a pe ni biopsy. Awọn oriṣi akọkọ mẹta ti awọn ilana biopsy:

• Oniye ayẹwo ifunni abẹrẹ ti o dara, eyiti o nlo abẹrẹ ti o nira pupọ lati yọ ayẹwo ti awọn sẹẹli tabi omi
• Biopsy abẹrẹ mojuto, eyiti o lo abẹrẹ nla lati yọ ayẹwo kan
• Atẹgun-ara abẹ, eyiti o yọ ayẹwo ni kekere, ilana ile-iwosan

Ifẹ abẹrẹ ti o dara ati awọn biopsies abẹrẹ pataki nigbagbogbo pẹlu awọn igbesẹ wọnyi:

• Iwọ yoo dubulẹ si ẹgbẹ rẹ tabi joko lori tabili idanwo kan.
• Olupese ilera kan yoo nu aaye biopsy naa ki o si fun u pẹlu anesitetiki ki o ko ni rilara eyikeyi irora lakoko ilana naa.
• Ni kete ti agbegbe ba ti kuru, olupese yoo fi sii abẹrẹ ifẹ ti o dara tabi abẹrẹ biopsy pataki sinu aaye biopsy ati yọ ayẹwo ti ara tabi omi.
• O le ni irọrun titẹ diẹ nigbati a ba yọ apẹẹrẹ kuro.
• Yoo lo titẹ si aaye biopsy titi ti ẹjẹ yoo fi duro.
• Olupese rẹ yoo lo bandage ti o ni ilera ni aaye biopsy.

Ninu biopsy iṣẹ abẹ, oniṣẹ abẹ yoo ṣe gige kekere ninu awọ rẹ lati yọ gbogbo tabi apakan ti odidi igbaya kan kuro. Ayẹwo iṣọn-ẹjẹ nigbakugba ti a ko ba le de odidi pẹlu biopsy abẹrẹ. Awọn biopsies ti iṣẹ-iṣe nigbagbogbo pẹlu awọn igbesẹ wọnyi.

• Iwọ yoo dubulẹ lori tabili iṣiṣẹ. IV (ila iṣan) le ṣee gbe si apa tabi ọwọ rẹ.
• O le fun ni oogun, ti a pe ni sedative, lati ṣe iranlọwọ fun ọ lati sinmi.
• A o fun ọ ni agbegbe tabi akunilogbo gbogbogbo nitorinaa iwọ kii yoo ni irora lakoko ilana naa.
  • Fun akuniloorun agbegbe, olupese iṣẹ ilera kan yoo fa aaye biopsy pẹlu oogun lati sọ agbegbe naa di.
  • Fun akuniloorun gbogbogbo, ọlọgbọn pataki kan ti a pe ni anesthesiologist yoo fun ọ ni oogun nitorinaa iwọ yoo daku lakoko ilana naa.
• Lọgan ti agbegbe biopsy naa ti rẹwẹsi tabi o ko mọ, oniṣẹ abẹ naa yoo ṣe gige kekere sinu igbaya ati yọ apakan tabi gbogbo odidi kan. Diẹ ninu awọn ara ti o wa ni ayika odidi naa le tun yọkuro.
• Ge ni awọ rẹ yoo wa ni pipade pẹlu awọn aran tabi awọn ila alemora.

Awọn oriṣiriṣi awọn biopsies wa. Iru biopsy ti o gba yoo dale lori ipo ati iwọn ti tumo rẹ.

Ṣe Mo nilo lati ṣe ohunkohun lati mura fun idanwo naa?

Iwọ kii yoo nilo awọn ipalemo pataki eyikeyi ti o ba ngba anestesia ti agbegbe (nọnju ti aaye biopsy). Ti o ba ngba anestesia gbogbogbo, o ṣee ṣe ki o nilo lati yara (ko jẹ tabi mu) fun awọn wakati pupọ ṣaaju iṣẹ abẹ. Oniṣẹ abẹ rẹ yoo fun ọ ni awọn itọnisọna pato diẹ sii. Pẹlupẹlu, ti o ba n gba sedative tabi akunilogbo gbogbogbo, rii daju lati ṣeto fun ẹnikan lati gbe ọ ni ile. O le jẹ groggy ati idamu lẹhin ti o ji lati ilana naa.

Ṣe eyikeyi awọn eewu si idanwo naa?

O le ni ipalara kekere tabi ẹjẹ ni aaye biopsy. Nigbakan aaye naa ni akoran. Ti iyẹn ba ṣẹlẹ, iwọ yoo tọju pẹlu awọn egboogi. Biopsy iṣẹ abẹ le fa diẹ ninu irora ati aapọn diẹ sii. Olupese ilera rẹ le ṣeduro tabi ṣe oogun oogun lati ṣe iranlọwọ fun ọ lati ni irọrun dara.

Kini awọn abajade tumọ si?

Ti awọn abajade rẹ ba fihan awọn sẹẹli tumọ rẹ ni awọn ipele giga ti PDL1, o le bẹrẹ lori imunotherapy. Ti awọn abajade rẹ ko ba han awọn ipele giga ti PDL1, imunotherapy le ma munadoko fun ọ. Ṣugbọn o le ni anfani lati oriṣi miiran ti itọju aarun. Ti o ba ni awọn ibeere nipa awọn abajade rẹ, sọrọ si olupese iṣẹ ilera rẹ.

Kọ ẹkọ diẹ sii nipa awọn idanwo yàrá, awọn sakani itọkasi, ati oye awọn abajade.

Njẹ ohunkohun miiran ti Mo nilo lati mọ nipa idanwo PDL1 kan?

Imunotherapy ko ṣiṣẹ fun gbogbo eniyan, paapaa ti o ba ni awọn èèmọ pẹlu awọn ipele giga ti PDL1. Awọn sẹẹli akàn jẹ eka ati igbagbogbo airotẹlẹ. Awọn olupese ilera ati awọn oluwadi tun nkọ nipa imunotherapy ati bii a ṣe le sọ asọtẹlẹ tani yoo ni anfani julọ julọ lati itọju yii.

Awọn itọkasi

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5. Akàn.Net [Intanẹẹti]. Alexandria (VA): American Society of Clinical Oncology; c2005-2018. Awọn nkan 9 lati Mọ Nipa Imunotherapy ati Aarun Ẹdọ; 2016 Oṣu kọkanla 8 [toka si 2018 Aug 14]; [nipa iboju 3]. Wa lati: https://www.cancer.net/blog/2016-11/9-things-know-about-immunotherapy-and-lung-cancer
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8. Awọn idanwo Lab lori Ayelujara [Intanẹẹti]. Washington DC: Association Amẹrika fun Kemistri Iṣoogun; c2001–2018. Awọn idanwo Jiini fun Itọju ailera Akàn; [imudojuiwọn 2018 Jun 18; tọka si 2018 Aug 14]; [nipa iboju 2]. Wa lati: https://labtestsonline.org/tests/genetic-tests-targeted-cancer-therapy
9. Ile-iwosan Mayo: Awọn ile-iwosan Iṣoogun Mayo [Intanẹẹti]. Foundation Mayo fun Ẹkọ Iṣoogun ati Iwadi; c1995–2018. Idanwo Idanwo: PDL1: Eto Iku-Ligand 1 (PD-L1) (SP263), Ologbele-Pipo Immunohistochemistry, Afowoyi: Ile-iwosan ati Itumọ; [toka si 2018 Aug 14]; [nipa iboju 4]. Wa lati: https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Inprepretive/71468
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Alaye lori aaye yii ko yẹ ki o lo bi aropo fun itọju iṣoogun ọjọgbọn tabi imọran. Kan si olupese ilera kan ti o ba ni awọn ibeere nipa ilera rẹ.