IgA vasculitis - Henoch-Schönlein purpura

IgA vasculitis jẹ aisan ti o ni awọn aami eleyi ti o ni awọ, irora apapọ, awọn iṣoro nipa ikun ati glomerulonephritis (iru ibajẹ akọn). O tun mọ ni Henoch-Schönlein purpura (HSP).

IgA vasculitis jẹ nipasẹ idahun ajeji ti eto aarun. Abajade jẹ iredodo ninu awọn ohun elo ẹjẹ airi ninu awọ ara. Awọn iṣọn ẹjẹ ninu awọn isẹpo, awọn kidinrin, tabi awọn ifun tun le ni ipa. Koyewa idi ti eyi fi waye.

Ajẹsara naa ni a rii julọ ninu awọn ọmọde laarin awọn ọjọ-ori 3 si ọdun 15, ṣugbọn o le rii ni awọn agbalagba. O wọpọ julọ ni awọn ọmọkunrin ju ti awọn ọmọbirin lọ. Ọpọlọpọ eniyan ti o dagbasoke arun yii ni ikolu atẹgun oke ni awọn ọsẹ ṣaaju.

Awọn aami aisan ati awọn ẹya ti IgA vasculitis le ni:

• Awọn aami eleyi lori awọ ara (purpura). Eyi waye ni fere gbogbo awọn ọmọde pẹlu ipo naa. Eyi nigbagbogbo nwaye lori apọju, awọn ẹsẹ isalẹ, ati awọn igunpa.
• Inu ikun.
• Apapọ apapọ.
• Ito ajeji (le ni awọn aami aisan).
• Gbuuru, nigbami ẹjẹ.
• Hives tabi angioedema.
• Ríru ati eebi.
• Wiwu ati irora ninu apo-ọmọkunrin.
• Orififo.

Olupese ilera yoo wo ara rẹ ki o wo awọ rẹ. Idanwo ti ara yoo fihan awọn ọgbẹ awọ ara (purpura, awọn egbo) ati ifọkanbalẹ apapọ.

Awọn idanwo le pẹlu:

• A gbọdọ ṣe ito ito ni gbogbo awọn ọran.
• Pipe ẹjẹ. Platelet le jẹ deede.
• Awọn idanwo coagulation: iwọnyi yẹ ki o jẹ deede.
• Ayẹwo ara, paapaa ni awọn agbalagba.
• Awọn idanwo ẹjẹ lati wa awọn idi miiran ti iredodo iṣan ẹjẹ, gẹgẹbi lupus erythematosus eleto, vasculitis ti o ni ibatan ANCA tabi jedojedo.
• Ninu awọn agbalagba, o yẹ ki a ṣe ayẹwo biopsy kidinrin.
• Awọn idanwo aworan ti ikun ti irora ba wa.

Ko si itọju kan pato. Pupọ awọn ọran lọ kuro funrarawọn. Apapọ apapọ le ni ilọsiwaju pẹlu awọn NSAID bii naproxen. Ti awọn aami aisan ko ba lọ, o le fun ni ni oogun corticosteroid gẹgẹbi prednisone.

Arun julọ nigbagbogbo n dara si ara rẹ. Ida meji ninu meta ti awọn ọmọde pẹlu IgA vasculitis ni iṣẹlẹ kan ṣoṣo. Idamẹta awọn ọmọde ni awọn iṣẹlẹ diẹ sii. Awọn eniyan yẹ ki o ni atẹle iṣoogun to sunmọ fun awọn oṣu mẹfa 6 lẹhin awọn iṣẹlẹ lati wa awọn ami ti arun aisan. Awọn agbalagba ni eewu ti o tobi julọ lati dagbasoke arun aisan onibaje.

Awọn ilolu le ni:

• Ẹjẹ inu ara
• Ìdènà ti ifun (ninu awọn ọmọde)
  
• Awọn iṣoro Kidirin (ni awọn iṣẹlẹ to ṣọwọn)

Pe olupese rẹ ti:

• O dagbasoke awọn aami aiṣan ti IgA vasculitis, ati pe wọn duro fun diẹ ẹ sii ju ọjọ diẹ lọ.
• O ni ito awọ tabi ito ito kekere lẹhin iṣẹlẹ kan.

Immunoglobulin A vasculitis; Leukocytoclastic vasculitis; Henoch-Schönlein purpura; HSP

• Henoch-Schonlein purpura lori awọn ẹsẹ isalẹ
• Henoch-Schonlein purpura
• Henoch-Schonlein purpura
• Henoch-Schonlein purpura
• Henoch-Schonlein purpura lori ẹsẹ ọmọ-ọwọ kan
• Henoch-Schonlein purpura lori awọn ẹsẹ ọmọde
• Henoch-Schonlein purpura lori awọn ẹsẹ ọmọde
• Henoch-Schonlein purpura lori awọn ẹsẹ

Arntfield RT, Hicks CM. Lupus erythematosus ti eto ati awọn vasculitides. Ni: Odi RM, Hockberger RS, Gausche-Hill M, awọn eds. Oogun pajawiri ti Rosen: Awọn Agbekale ati Iwa-iwosan. 9th ed. Philadelphia, PA: Elsevier; 2018: ori 108.

Dinulos JGH. Awọn syndromes ifamọra ara ẹni ati vasculitis. Ni: Habif TP, Dinulos JGH, Chapman MS, Zug KA, awọn eds. Arun Ara: Ayẹwo ati Itọju. Kẹrin ed. Philadelphia, PA: Elsevier; 2018: ori 11.

Feehally J, FLoege J. Immunoglobulin A nephropathy ati IgA vasculitis (Henoch-Schönlein purpura). Ni: Feehally J, Floege J, Tonelli M, Johnson RJ, awọn eds. Okeerẹ Clinical Nephrology. 6th ed. Philadelphia, PA: Elsevier; 2019: ori 23.

Hahn D, Hodson EM, Willis NS, Craig JC. Awọn ilowosi fun idilọwọ ati atọju arun aisan ni Henoch-Schönlein purpura (HSP). Ile-iṣẹ Cochrane Syst Rev.. 2015; (8): CD005128. PMID: 26258874 www.ncbi.nlm.nih.gov/pubmed/ 26258874.

Lu S, Liu D, Xiao J, et al. Ifiwera laarin awọn agbalagba ati awọn ọmọde pẹlu Henoch-Schönlein purpura nephritis. Pediatr Nephrol. 2015; 30 (5): 791-796. PMID: 25481021 www.ncbi.nlm.nih.gov/pubmed/25481021.

Patterson JW. Ilana ifasita vasculopathic. Ni: Patterson JW, ṣatunkọ. Weedon’s Pathology. Kẹrin ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2016: ori 8.

Sunderkötter CH, Zelger B, Chen KR, et al. Nomenclature ti cutaneous vasculitis: Addmatologic addendum si 2012 atunyẹwo International Chapel Hill Consensus Conference Nomenclature ti Vasculitides. Arthritis Rheumatol. 2018; 70 (2): 171-184. PMID: 29136340 www.ncbi.nlm.nih.gov/pubmed/29136340.