Igbeyewo Ara Ara Ara (SMA)

Akoonu

• Kini idanwo alatako iṣan ti o nira (SMA)?
• Kini o ti lo fun?
• Kini idi ti Mo nilo idanwo SMA?
• Kini o ṣẹlẹ lakoko idanwo SMA?
• Ṣe Mo nilo lati ṣe ohunkohun lati mura fun idanwo naa?
• Ṣe eyikeyi awọn eewu si idanwo naa?
• Kini awọn abajade tumọ si?
• Njẹ ohunkohun miiran ti Mo nilo lati mọ nipa idanwo SMA kan?
• Awọn itọkasi

Kini idanwo alatako iṣan ti o nira (SMA)?

Idanwo yii n wa awọn egboogi iṣan didan (SMAs) ninu ẹjẹ. Eda ara iṣan ti o dan (SMA) jẹ iru agboguntaisan ti a mọ si autoantibody. Ni deede, eto ajẹsara rẹ ṣe awọn egboogi lati kọlu awọn nkan ajeji bi awọn ọlọjẹ ati kokoro arun. Aifọwọyi kan kolu awọn sẹẹli ti ara ati awọn ara nipasẹ aṣiṣe. Awọn SMA kolu awọn iṣan iṣan didan ninu ẹdọ ati awọn ẹya miiran ti ara.

Ti a ba rii awọn SMA ninu ẹjẹ rẹ, o ṣee ṣe o ni aarun aarun aarun ayọkẹlẹ. Arun jedojedo autoimmune jẹ arun kan ninu eyiti eto mimu ma kọlu awọn ara ẹdọ. Awọn oriṣi meji ti jedojedo autoimmune:

• Tẹ 1, fọọmu ti o wọpọ julọ ti arun na. Iru 1 kan awọn obinrin diẹ sii ju awọn ọkunrin lọ. O tun wọpọ julọ ni awọn eniyan ti o tun ni aiṣedede autoimmune miiran.
• Tẹ 2, fọọmu ti ko wọpọ ti arun na. Iru 2 julọ ni ipa lori awọn ọmọbirin laarin awọn ọjọ ori 2 si 14.

Aarun jedojedo aarun autoimmune le ṣakoso pẹlu awọn oogun ti o mu eto alaabo kuro. Itọju jẹ doko diẹ sii nigbati a ba ri rudurudu naa ni kutukutu. Laisi itọju, jedojedo autoimmune le fa awọn iṣoro ilera to ṣe pataki, pẹlu cirrhosis ati ikuna ẹdọ.

Awọn orukọ miiran: egboogi-dan ara agboguntaisan, ASMA, agbo-ara actin, ACTA

Kini o ti lo fun?

Idanwo SMA ni lilo akọkọ lati ṣe iwadii arun jedojedo autoimmune. O tun lo lati wa boya rudurudu naa jẹ iru 1 tabi iru 2.

Awọn idanwo SMA tun lo nigbagbogbo pẹlu awọn idanwo miiran lati ṣe iranlọwọ lati jẹrisi tabi ṣe akoso idanimọ ti jedojedo autoimmune. Awọn idanwo miiran wọnyi pẹlu:

• Idanwo fun awọn ara inu ara F-actin. F-actin jẹ amuaradagba ti a rii ninu awọn iṣan isan didan ti ẹdọ ati awọn ẹya miiran ti ara. Awọn ara inu ara F-actin kolu awọn awọ ara ilera wọnyi.
• ANA (egboogi alatako iparun). Awọn ANA jẹ awọn ara inu ara ti o kolu arin (aarin) ti awọn sẹẹli ilera kan.
• Awọn idanwo ALT (alanine transaminase) ati awọn idanwo AST (aspartate aminotransferase). ALT ati AST jẹ awọn ensaemusi meji ti a ṣe nipasẹ ẹdọ.

Kini idi ti Mo nilo idanwo SMA?

O le nilo idanwo yii ti iwọ tabi ọmọ rẹ ba ni awọn aami aiṣan ti arun jedojedo autoimmune. Iwọnyi pẹlu:

• Rirẹ
• Jaundice (majemu ti o fa ki awọ ati oju rẹ di ofeefee)
• Inu ikun
• Apapọ apapọ
• Ríru
• Awọn awọ ara
• Isonu ti yanilenu
• Ito-awọ dudu

Kini o ṣẹlẹ lakoko idanwo SMA?

Onimọṣẹ ilera kan yoo mu ayẹwo ẹjẹ lati iṣọn kan ni apa rẹ, ni lilo abẹrẹ kekere kan. Lẹhin ti a fi sii abẹrẹ, iye ẹjẹ kekere yoo gba sinu tube idanwo tabi igo kan. O le ni irọra diẹ nigbati abẹrẹ ba wọ inu tabi jade. Eyi maa n gba to iṣẹju marun.

Ṣe Mo nilo lati ṣe ohunkohun lati mura fun idanwo naa?

O ko nilo awọn ipese pataki eyikeyi fun idanwo SMA.

Ṣe eyikeyi awọn eewu si idanwo naa?

Ewu pupọ wa si nini idanwo ẹjẹ. O le ni irora diẹ tabi ọgbẹ ni aaye ibiti a ti fi abẹrẹ sii, ṣugbọn ọpọlọpọ awọn aami aisan lọ ni kiakia.

Kini awọn abajade tumọ si?

Ti awọn abajade rẹ ba fi iye giga ti awọn egboogi SMA han, o ṣee ṣe tumọ si pe o ni iru 1 iru ti aarun jedojedo autoimmune. Iwọn kekere le tumọ si pe o ni iru 2 iru arun naa.

Ti a ko ba ri awọn SMA, o tumọ si pe awọn aami aiṣan ẹdọ rẹ ni a fa nipasẹ nkan ti o yatọ ju aarun aarun ayọkẹlẹ lọ. Olupese ilera rẹ yoo nilo lati paṣẹ awọn idanwo diẹ sii lati ṣe idanimọ kan.

Ti o ba ni awọn ibeere nipa awọn abajade rẹ, sọrọ si olupese iṣẹ ilera rẹ.

Kọ ẹkọ diẹ sii nipa awọn idanwo yàrá, awọn sakani itọkasi, ati oye awọn abajade.

Njẹ ohunkohun miiran ti Mo nilo lati mọ nipa idanwo SMA kan?

Ti awọn abajade rẹ ba fihan pe iwọ tabi ọmọ rẹ ni awọn egboogi SMA, olupese rẹ le paṣẹ biopsy ẹdọ lati jẹrisi idanimọ ti jedojedo aarun ayọkẹlẹ. Biopsy jẹ ilana ti o yọ apẹẹrẹ kekere ti àsopọ fun idanwo.

Awọn itọkasi

1. Ipilẹ Ẹdọ Amẹrika. [Intanẹẹti]. Niu Yoki: Foundation Ẹdọ Amẹrika; c2017. Autoimmune Hepatitis [ti a tọka 2019 Aug 19]; [nipa iboju 4]. Wa lati: https://liverfoundation.org/for-patients/about-the-liver/diseases-of-the-liver/autoimmune-hepatitis/#information-for-the-newly-diagnosed
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4. Awọn idanwo Lab lori Ayelujara [Intanẹẹti]. Washington D.C.; Ẹgbẹ Amẹrika fun Kemistri Iwosan; c2001–2019. Antibody Isan Ara (SMA) ati F-actin Antibody [imudojuiwọn 2019 May 13; toka si 2019 Aug 19]; [nipa iboju 2]. Wa lati: https://labtestsonline.org/tests/smooth-muscle-antibody-sma-and-f-actin-antibody
5. Ile-iwosan Mayo [Intanẹẹti]. Foundation Mayo fun Ẹkọ Iṣoogun ati Iwadi; c1998–2019. Arun jedojedo autoimmune: Awọn aami aisan ati awọn okunfa; 2018 Oṣu Kẹsan 12 [toka 2019 Aug 19]; [nipa iboju 3]. Wa lati: https://www.mayoclinic.org/diseases-conditions/autoimmune-hepatitis/symptoms-causes/syc-20352153
6. National Cancer Institute [Intanẹẹti]. Bethesda (MD): Ẹka Ilera ti U.S. ati Awọn Iṣẹ Eda Eniyan; NCI Dictionary ti Awọn ofin akàn: biopsy; [toka si 2020 Aug 9]; [nipa iboju 3]. Wa lati: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/biopsy
7. Okan Orilẹ-ede, Ẹdọfóró, ati Ẹjẹ Ẹjẹ [Intanẹẹti]. Bethesda (MD): Ẹka Ilera ti U.S. ati Awọn Iṣẹ Eda Eniyan; Awọn idanwo ẹjẹ [ti a tọka 2019 Aug 19]; [nipa iboju 3]. Wa lati: https://www.nhlbi.nih.gov/health-topics/blood-tests
8. National Institute of Arthritis ati Musculoskeletal ati Arun Ara [Intanẹẹti]. Bethesda (MD): Ẹka Ilera ti U.S. ati Awọn Iṣẹ Eda Eniyan; Awọn Arun Autoimmune [toka 2019 Aug 19]; [nipa iboju 3]. Wa lati: https://www.niams.nih.gov/health-topics/autoimmune-diseases
9. National Institute of Diabetes and Digestive and Kidney Arun [Intanẹẹti]. Bethesda (MD): Ẹka Ilera ti U.S. ati Awọn Iṣẹ Eda Eniyan; Itumọ ati Awọn Otitọ fun Ẹdọwansida Ẹtan; 2018 May [toka 2019 Aug 19]; [nipa iboju 4]. Wa lati: https://www.niddk.nih.gov/health-information/liver-disease/autoimmune-hepatitis/definition-facts
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11. National Institute of Diabetes and Digestive and Kidney Arun [Intanẹẹti]. Bethesda (MD): Ẹka Ilera ti U.S. ati Awọn Iṣẹ Eda Eniyan; Awọn aami aisan ati Awọn Okunfa ti Ẹdọwadii Ẹdọ-ara; 2018 May [toka 2019 Aug 19]; [nipa iboju 4]. Wa lati: https://www.niddk.nih.gov/health-information/liver-disease/autoimmune-hepatitis/symptoms-causes
12. Ilera UF: Ile-ẹkọ Yunifasiti ti Ilera ti Florida [Intanẹẹti]. Gainesville (FL): Ile-iwe giga Yunifasiti ti Ilera ti Florida; c2019. Egboogi iṣan didan-dan: Akopọ [imudojuiwọn 2019 Aug 19; toka si 2019 Aug 19]; [nipa iboju 2]. Wa lati: https://ufhealth.org/anti-smooth-muscle-antibody
13. Ilera UF: Ile-ẹkọ Yunifasiti ti Ilera ti Florida [Intanẹẹti]. Gainesville (FL): Ile-iwe giga Yunifasiti ti Ilera ti Florida; c2019. Arun jedojedo autoimmune: Akopọ [imudojuiwọn 2019 Aug 19; toka si 2019 Aug 19]; [nipa iboju 2]. Wa lati: https://ufhealth.org/autoimmune-hepatitis
14. Yunifasiti ti Rochester Medical Center [Intanẹẹti]. Rochester (NY): Yunifasiti ti Ile-iṣẹ Iṣoogun ti Rochester; c2019. Encyclopedia Health: Autoimmune Hepatitis [ti a toka si 2019 Oṣu Kẹjọ 19]; [nipa iboju 2]. Wa lati: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=85&contentid=P00657
15. Zeman MV, Hirschfield GM. Awọn ẹya ara ẹni ati arun ẹdọ: Awọn lilo ati awọn ilokulo. Le J Gastroenterol [Intanẹẹti]. 2010 Apr [ti a tọka si 2019 Aug 19]; 24 (4): 225–31. Wa lati: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864616

Alaye lori aaye yii ko yẹ ki o lo bi aropo fun itọju iṣoogun ọjọgbọn tabi imọran. Kan si olupese ilera kan ti o ba ni awọn ibeere nipa ilera rẹ.