5-HTP

Akoonu

• O ṣee ṣe ki o munadoko fun ...
• O ṣee ṣe ki o munadoko fun ...
• Ẹri ti ko to lati ṣe iṣiro oṣuwọn fun ...
• Awọn iṣọra pataki & awọn ikilo:

5-HTP (5-hydroxytryptophan) jẹ ọja-kemikali kemikali ti ile amọradagba L-tryptophan. O tun ṣe agbejade ni iṣowo lati awọn irugbin ti ohun ọgbin Afirika ti a mọ ni Griffonia simplicifolia.

5-HTP ni a lo fun awọn rudurudu oorun bi airorun, ibanujẹ, aibalẹ, ati ọpọlọpọ awọn ipo miiran, ṣugbọn ko si ẹri ijinle sayensi ti o dara lati ṣe atilẹyin pupọ julọ awọn lilo wọnyi.

Awọn Ile-ẹkọ Iṣeduro Alaye Awọn Oogun Adayeba awọn oṣuwọn doko da lori ẹri ijinle sayensi ni ibamu si iwọn wọnyi: Imudara, O ṣeeṣe Ki o munadoko, O ṣeeṣe Ki o munadoko, O ṣeeṣe Ki o munadoko, O ṣeeṣe pe ko wulo, ko wulo, ati Ẹri ti ko to lati Oṣuwọn.

Awọn igbelewọn ṣiṣe fun 5-HTP ni atẹle:

O ṣee ṣe ki o munadoko fun ...

• Ibanujẹ. Mu 5-HTP ni ẹnu dabi pe o mu awọn aami aiṣan ti ibanujẹ dara si diẹ ninu awọn eniyan. Diẹ ninu iwadii ile-iwosan fihan pe gbigba 5-HTP nipasẹ ẹnu le jẹ anfani bi awọn oogun egboogi antidepressant kan fun imudarasi awọn aami aiṣedede. Ninu ọpọlọpọ awọn ẹkọ, a mu 150-800 mg miligiramu ojoojumọ ti 5-HTP. Ni awọn igba miiran, a ti lo awọn abere to ga julọ.

O ṣee ṣe ki o munadoko fun ...

• Aisan isalẹ. Diẹ ninu awọn iwadii fihan pe fifun 5-HTP si awọn ọmọ-ọwọ ti o ni ailera isalẹ le mu iṣan ati iṣẹ dara si. Iwadi miiran fihan pe ko mu iṣan tabi idagbasoke dagba nigba ti a mu lati igba ọmọde titi di ọdun 3-4. Iwadi tun fihan pe gbigba 5-HTP pẹlu awọn oogun oogun ti o ṣe deede ṣe ilọsiwaju idagbasoke, awọn ọgbọn awujọ, tabi awọn ọgbọn ede.

Ẹri ti ko to lati ṣe iṣiro oṣuwọn fun ...

• Iru aifọkanbalẹ ti samisi nipasẹ awọn ironu loorekoore ati awọn ihuwasi atunwi (rudurudu ti ipa-agbara tabi OCD). Iwadi ni kutukutu fihan pe gbigbe 5-HTP pẹlu oogun oogun antidepressant fluoxetine (Prozac) fun awọn ọsẹ 12 le mu diẹ ninu awọn aami aisan ti OCD ni ilọsiwaju.
• Ọpọlọ lilo rudurudu. Iwadi ni kutukutu fihan pe gbigbe 5-HTP pẹlu D-phenylalanine ati L-glutamine fun awọn ọjọ 40 le dinku awọn aami aarun yiyọ kuro. Sibẹsibẹ, gbigba 5-HTP pẹlu carbidopa lojoojumọ fun ọdun kan ko dabi pe o ṣe iranlọwọ fun eniyan lati da mimu. Ipa ti 5-HTP nikan fun ọti-lile ko han.
• Arun Alzheimer. Iwadi ni kutukutu daba pe gbigba 5-HTP ni ẹnu ko ṣe iranlọwọ awọn aami aisan ti arun Alzheimer.
• Ṣàníyàn. Ẹri lori awọn ipa ti 5-HTP fun aibalẹ koyewa. Iwadi ni kutukutu fihan pe gbigba 25-150 iwon miligiramu ti 5-HTP nipasẹ ẹnu lojoojumọ pẹlu carbidopa dabi pe o dinku awọn aami aiṣan aifọkanbalẹ ninu awọn eniyan ti o ni awọn rudurudu aifọkanbalẹ. Sibẹsibẹ, iwadi iṣaaju miiran fihan pe gbigbe awọn abere to ga julọ ti 5-HTP, 225 iwon miligiramu lojoojumọ tabi diẹ sii, o dabi pe o mu ki aifọkanbalẹ buru. Pẹlupẹlu, gbigba 60 iwon miligiramu ti 5-HTP lojoojumọ nipasẹ iṣọn ko dinku aifọkanbalẹ ninu awọn eniyan ti o ni awọn rudurudu ijaaya.
• Ibajẹ ọpọlọ ti o kan ipa iṣan (cerebellar ataxia). Ẹri lori lilo 5-HTP fun cerebellar ataxia koyewa. Ẹri akọkọ fihan pe gbigba 5 mg / kg ti 5-HTP lojoojumọ fun awọn oṣu 4 le dinku aiṣedede eto aifọkanbalẹ. Sibẹsibẹ, iwadi miiran fihan pe gbigba 5-HTP lojoojumọ fun ọdun kan ko ni mu awọn aami aiṣan ti ataxia cerebellar jẹ.
• Fibromyalgia. Iwadi ni kutukutu ṣe imọran pe gbigba 100 iwon miligiramu ti 5-HTP nipasẹ ẹnu ni igba mẹta lojoojumọ fun awọn ọjọ 30-90 le mu ilọsiwaju dara, irẹlẹ, oorun, aibalẹ, rirẹ, ati lile agara ni awọn eniyan ti o ni fibromyalgia.
• Awọn aami aiṣedede. Iwadi ni kutukutu daba pe gbigba 150 miligiramu ti 5-HTP lojoojumọ fun awọn ọsẹ 4 ko dinku awọn itanna to gbona ninu awọn obinrin ti o ti ran obinrin lẹjọ igbeyawo.
• Iṣeduro. Ẹri lori awọn ipa ti 5-HTP fun idena tabi itọju awọn iṣilọ ninu awọn agbalagba koyewa. Diẹ ninu awọn ijinlẹ fihan pe gbigba 5-HTP lojoojumọ ko dinku awọn ijira, lakoko ti awọn ijinlẹ miiran fihan pe o le jẹ anfani bi awọn oogun oogun. 5-HTP ko dabi lati dinku awọn iṣilọ ninu awọn ọmọde.
• Isanraju. Iwadi ni kutukutu ni imọran pe gbigbe 5-HTP le ṣe iranlọwọ idinku ifẹkufẹ, gbigbe kalori, ati iwuwo ninu awọn eniyan ti o sanra. Iwadi miiran ni imọran pe lilo fifọ ẹnu kan pato ti o ni 5-HTP ati awọn iyokuro miiran (5-HTP-Nat Exts, Medestea Biotech Sip, Torino, Italia) fun awọn ọsẹ 4 mu alekun iwuwo pọ si nipa 41% ninu awọn obinrin postmenopausal.
• Yiyọ kuro lati heroin, morphine, ati awọn oogun opioid miiran. Iwadi ni kutukutu daba pe gbigba 200 miligiramu ti 5-HTP lojoojumọ fun awọn ọjọ 6 papọ pẹlu tyrosine, phosphatidylcholine, ati L-glutamine, le dinku insomnia ati awọn aami aiṣankuro kuro ni gbigba awọn afẹsodi heroin pada.
• Arun Parkinson. Iwadi ni kutukutu fihan pe gbigbe 100-150 iwon miligiramu ti 5-HTP nipasẹ ẹnu lojoojumọ pẹlu awọn oogun oogun ti o dabi lati dinku gbigbọn, ṣugbọn awọn anfani wọnyi tẹsiwaju nikan fun awọn oṣu 5. Iwadi kutukutu miiran fihan pe gbigba 50 iwon miligiramu ti 5-HTP lojoojumọ le dinku awọn aami aiṣan ti awọn rudurudu gbigbe lati oogun levodopa, ati awọn aami aiṣan ti ibanujẹ, ninu awọn eniyan ti o ni arun Parkinson. Ṣugbọn gbigbe awọn abere ti o tobi julọ ti 5-HTP, 275-1500 mg lojoojumọ, pẹlu carbidopa le buru diẹ ninu awọn aami aisan sii.
• Efori ẹdọfu. Iwadi ni kutukutu daba pe gbigba 100 miligiramu ti 5-HTP ni igba mẹta lojoojumọ fun awọn ọsẹ 8 ko dinku irora tabi ipari awọn efori ẹdọfu.
• Ẹjẹ aipe akiyesi-hyperactivity (ADHD).
• Airorunsun.
• Ẹjẹ dysphoric ti Premenstrual (PMDD).
• Arun Iṣaaju (PMS).
• Ramsey-Hunt dídùn.
• Awọn ipo miiran.

A nilo ẹri diẹ sii lati ṣe iṣiro ipa ti 5-HTP fun awọn lilo wọnyi.

5-HTP n ṣiṣẹ ni ọpọlọ ati eto aifọkanbalẹ aarin nipasẹ jijẹ iṣelọpọ ti serotonin kemikali. Serotonin le ni ipa lori oorun, igbadun, otutu, ihuwasi ibalopọ, ati rilara irora. Niwọn igba ti 5-HTP ṣe alekun iṣelọpọ ti serotonin, o ti lo fun ọpọlọpọ awọn arun nibiti a gbagbọ pe serotonin ṣe ipa pataki pẹlu ibanujẹ, insomnia, isanraju, ati ọpọlọpọ awọn ipo miiran.

Nigbati o ba ya nipasẹ ẹnu: 5-HTP ni Ailewu Ailewu nigbati o ba mu ni ẹnu deede. O ti lo lailewu ni awọn abere to 400 miligiramu lojoojumọ fun ọdun kan. Ṣugbọn diẹ ninu awọn eniyan ti o ti mu 5-HTP ti dagbasoke ipo ti a pe ni eosinophilia-myalgia syndrome (EMS). EMS jẹ ipo to ṣe pataki ti o kan irọra pupọ ti iṣan (myalgia) ati awọn ohun ajeji ẹjẹ (eosinophilia). Diẹ ninu awọn eniyan ro pe EMS le fa nipasẹ eroja airotẹlẹ tabi idibajẹ ni diẹ ninu awọn ọja 5-HTP. Ṣugbọn ko si ẹri ijinle sayensi ti o to lati mọ ti o ba jẹ pe EMS jẹ eyiti o ṣẹlẹ nipasẹ 5-HTP, olubajẹ, tabi diẹ ninu ifosiwewe miiran. Titi di mimọ diẹ sii, 5-HTP yẹ ki o lo ni iṣọra.

Awọn ipa ẹgbẹ miiran ti o ni agbara ti 5-HTP pẹlu aiya, irora inu, ọgbun, ìgbagbogbo, gbuuru, rirun, awọn iṣoro ibalopo, ati awọn iṣoro iṣan.

5-HTP ni O ṣee ṣe Aabo nigbati o ba gba ẹnu ni awọn abere nla. Awọn iwọn lilo lati 6-10 giramu lojoojumọ ti ni asopọ si awọn iṣoro ikun ti o nira ati awọn iṣan isan.

Awọn iṣọra pataki & awọn ikilo:

Oyun ati fifun-igbaya: Ko si alaye ti o gbẹkẹle to lati mọ boya 5-HTP jẹ ailewu lati lo nigbati o loyun tabi igbaya-ọmu. Duro ni apa ailewu ki o yago fun lilo.

Awọn ọmọde: 5-HTP ni Ailewu Ailewu nigbati o ba ya nipasẹ ẹnu ni deede. Awọn abere to to 5 iwon miligiramu / kg lojoojumọ ni a ti lo lailewu fun ọdun 3 ni awọn ọmọ-ọwọ ati awọn ọmọde titi di ọdun 12. Gẹgẹ bi pẹlu awọn agbalagba, ibakcdun tun wa nipa agbara fun eosinophilia-myalgia syndrome (EMS) ninu awọn ọmọde, ipo pataki kan ti o ni iyọra iṣan pupọ (myalgia) ati awọn ohun ajeji ẹjẹ (eosinophilia).

Isẹ abẹ: 5-HTP le ni ipa lori kemikali ọpọlọ ti a pe ni serotonin. Diẹ ninu awọn oogun ti a nṣe lakoko iṣẹ abẹ tun le ni ipa serotonin. Gbigba 5-HTP ṣaaju iṣẹ abẹ le fa serotonin pupọ pupọ ninu ọpọlọ ati pe o le ja si awọn ipa ti o lewu pataki pẹlu awọn iṣoro ọkan, riri, ati aibalẹ. Sọ fun awọn alaisan lati da gbigba 5-HTP o kere ju ọsẹ 2 ṣaaju iṣẹ abẹ.

Olórí

Maṣe gba apapo yii.

Awọn oogun fun ibanujẹ (MAOIs)

5-HTP mu ki kemikali pọ si ninu ọpọlọ ti a pe ni serotonin. Diẹ ninu awọn oogun ti a lo fun ibanujẹ tun mu serotonin pọ sii. Gbigba 5-HTP pẹlu awọn oogun wọnyi ti a lo fun ibanujẹ le mu serotonin pọ si pupọ. Eyi le fa awọn ipa ẹgbẹ to ṣe pataki pẹlu orififo ti o nira, awọn iṣoro ọkan, riri, idaru, ati aibalẹ.

Diẹ ninu awọn oogun wọnyi ti a lo fun ibanujẹ pẹlu phenelzine (Nardil), tranylcypromine (Parnate), ati awọn omiiran.

Dede

Ṣọra pẹlu apapo yii.

Carbidopa (Lodosyn)

5-HTP le ni ipa ọpọlọ. Carbidopa (Lodosyn) tun le kan ọpọlọ. Gbigba 5-HTP pẹlu carbidopa le mu eewu awọn ipa ti o lewu pọ pẹlu ọrọ iyara, aibalẹ, ibinu, ati awọn omiiran.

Awọn oogun ifura (CNS depressants)

5-HTP le fa oorun ati oorun. Awọn oogun ti o fa oorun oorun ni a pe ni sedative. Mu 5-HTP pẹlu awọn oogun oniduro le fa oorun pupọju.

Diẹ ninu awọn oogun oogun pẹlu clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), ati awọn omiiran.

Awọn oogun Serotonergic

5-HTP le mu kemikali pọ si ninu ọpọlọ ti a pe ni serotonin. Diẹ ninu awọn oogun tun mu serotonin pọ sii. Gbigba 5-HTP pẹlu awọn oogun wọnyi le mu serotonin pọ si pupọ. Eyi le fa awọn ipa ẹgbẹ to ṣe pataki pẹlu orififo ti o nira, awọn iṣoro ọkan, gbigbọn, iporuru, ati aibalẹ.

Diẹ ninu awọn oogun wọnyi pẹlu fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Tofranil), sumatriptan (Imitrex), zolmitriptan (Zomig), rizatriptan methadone (Dolophine), tramadol (Ultram), ati ọpọlọpọ awọn omiiran.

Ewebe ati awọn afikun pẹlu awọn ohun-ini sedative

5-HTP le fa oorun tabi oorun. Lilo rẹ pẹlu awọn ewe miiran ati awọn afikun ti o ni ipa kanna le fa oorun pupọ julọ. Diẹ ninu awọn ewe wọnyi ati awọn afikun pẹlu calamus, California poppy, catnip, hops, Jamaican dogwood, kava, St. John’s wort, skullcap, valerian, yerba mansa, ati awọn omiiran.

Ewebe ati awọn afikun pẹlu awọn ohun-ini serotonergic

5-HTP npo kemikali ọpọlọ ti a pe ni serotonin. Gbigba 5-HTP pẹlu awọn ewe miiran ati awọn afikun ti o mu serotonin le ja si serotonin pupọ ati fa awọn ipa ẹgbẹ pẹlu awọn iṣoro ọkan, gbigbọn ati aibalẹ. Awọn ewe miiran ati awọn afikun ti o mu awọn ipele serotonin pọ pẹlu ọmọ igi ọmọ Hawaii, L-tryptophan, S-adenosylmethionine (SAMe), ati St. John’s wort.

Ko si awọn ibaraẹnisọrọ ti a mọ pẹlu awọn ounjẹ.

Awọn abere wọnyi ni a ti kẹkọọ ninu iwadi ijinle sayensi: AWON AGBA

NIPA ẹnu:

• Fun ibanujẹ: Ti o wọpọ julọ, a mu iwọn 150-800 mg lojoojumọ fun ọsẹ 2-6. Awọn abere wọnyi nigbakan ni a pin si ati ṣakoso bi 50 miligiramu si 100 miligiramu ni igba mẹta ni ọjọ kan. Nigbakan iwọn lilo bẹrẹ ni kekere ati ni imurasilẹ npo ni gbogbo ọsẹ 1-2 titi ti o fi de iwọn lilo afojusun. Kere wọpọ, awọn abere to ga julọ ni a lo. Ninu iwadi kan, iwọn lilo naa pọ si ni imurasilẹ to giramu 3 fun ọjọ kan.

2-Amino-3- (5-Hydroxy-1H-Indol-3-yl) Acid Propanoic, 5 Hydroxy-Tryptophan, 5 Hydroxy-Tryptophane, 5-Hydroxytryptophan, 5-Hydroxytryptophane, 5-Hydroxy L-Tryptophan, 5-Hydroxy L-Tryptophane, 5-Hydroxy Tryptophan, 5-L-Hydroxytryptophan, L-5 HTP, L-5-Hydroxytryptophan, L-5-Hydroxytryptophane, Oxitriptan.

Lati kọ diẹ sii nipa bi a ṣe kọ nkan yii, jọwọ wo Awọn Ile-ẹkọ Iṣeduro Alaye Awọn Oogun Adayeba ilana.

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