Awọn idanwo Pharmacogenetic

Akoonu
- Kini idanwo oogun-oogun?
- Kini o ti lo fun?
- Kini idi ti Mo nilo idanwo oogun-oogun?
- Kini yoo ṣẹlẹ lakoko idanwo oogun-oogun?
- Ṣe Mo nilo lati ṣe ohunkohun lati mura fun idanwo naa?
- Ṣe eyikeyi awọn eewu si idanwo naa?
- Kini awọn abajade tumọ si?
- Njẹ ohunkohun miiran ti Mo nilo lati mọ nipa idanwo oogun-oogun?
- Awọn itọkasi
Kini idanwo oogun-oogun?
Pharmacogenetics, ti a tun pe ni pharmacogenomics, jẹ iwadi ti bawo ni awọn jiini ṣe kan idahun ara si awọn oogun kan. Jiini jẹ awọn apakan ti DNA ti o kọja lati iya ati baba rẹ. Wọn gbe alaye ti o ṣe ipinnu awọn ami iyasọtọ rẹ, gẹgẹbi giga ati awọ oju. Awọn Jiini rẹ tun le ni ipa bi ailewu ati munadoko ti oogun kan le jẹ fun ọ.
Awọn Jiini le jẹ idi oogun kanna ni iwọn kanna yoo ni ipa lori awọn eniyan ni awọn ọna ti o yatọ pupọ. Awọn Jiini le tun jẹ idi ti diẹ ninu awọn eniyan ni awọn ipa ti ko dara si oogun kan, lakoko ti awọn miiran ko ni.
Idanwo ti oogun oogun wo awọn Jiini pato lati ṣe iranlọwọ lati mọ iru awọn oogun ati awọn iwọn lilo ti o le jẹ deede fun ọ.
Awọn orukọ miiran: oogun-oogun, idanwo oogun-oogun
Kini o ti lo fun?
A le lo idanwo Pharmacogenetic lati:
- Wa boya oogun kan le jẹ doko fun ọ
- Wa iru iwọn lilo ti o dara julọ le jẹ fun ọ
- Sọtẹlẹ boya iwọ yoo ni ipa to ṣe pataki lati oogun kan
Kini idi ti Mo nilo idanwo oogun-oogun?
Olupese ilera rẹ le paṣẹ awọn idanwo wọnyi ṣaaju ki o to bẹrẹ oogun kan, tabi ti o ba n mu oogun ti ko ṣiṣẹ ati / tabi fa awọn ipa ẹgbẹ ti ko dara.
Awọn idanwo Pharmacogenetic wa fun nọmba to lopin ti awọn oogun. Ni isalẹ wa diẹ ninu awọn oogun ati awọn Jiini ti o le ṣe idanwo. (Awọn orukọ Gene ni a maa n fun ni awọn lẹta ati awọn nọmba.)
Òògùn | Jiini |
---|---|
Warfarin: eje tinrin | CYP2C9 ati VKORC1 |
Plavix, tinrin ẹjẹ kan | CYP2C19 |
Awọn egboogi apaniyan, awọn oogun warapa | GBJP2D6, CYPD6 CYP2C9, CYP1A2, SLC6A4, HTR2A / C |
Tamoxifen, itọju kan fun ọgbẹ igbaya | CYPD6 |
Antipsychotics | DRD3, CYP2D6, CYP2C19, CYP1A2 |
Awọn itọju fun rudurudu aipe akiyesi | D4D4 |
Carbamazepine, itọju kan fun warapa | HLA-B * 1502 |
Abacavir, itọju kan fun HIV | HLA-B * 5701 |
Awọn opioids | OPRM1 |
Statins, awọn oogun ti o tọju idaabobo awọ giga | SLCO1B1 |
Awọn itọju fun aisan lukimia ọmọde ati awọn aiṣedede autoimmune kan | TMPT |
Kini yoo ṣẹlẹ lakoko idanwo oogun-oogun?
Idanwo nigbagbogbo ni a ṣe lori ẹjẹ tabi itọ.
Fun idanwo ẹjẹ, ọjọgbọn ilera kan yoo gba ayẹwo ẹjẹ lati iṣọn kan ni apa rẹ, ni lilo abẹrẹ kekere kan. Lẹhin ti a fi sii abẹrẹ, iye ẹjẹ kekere yoo gba sinu tube idanwo tabi igo kan. O le ni irọra diẹ nigbati abẹrẹ ba wọ inu tabi jade. Eyi maa n gba to iṣẹju marun.
Fun idanwo itọ, beere lọwọ olupese ilera rẹ fun awọn itọnisọna lori bi o ṣe le pese apẹẹrẹ rẹ.
Ṣe Mo nilo lati ṣe ohunkohun lati mura fun idanwo naa?
Nigbagbogbo o ko nilo awọn ipese pataki eyikeyi fun idanwo ẹjẹ. Ti o ba ngba idanwo itọ, o ko gbọdọ jẹ, mu, tabi mu siga fun iṣẹju 30 ṣaaju idanwo naa.
Ṣe eyikeyi awọn eewu si idanwo naa?
Ewu pupọ wa si nini idanwo ẹjẹ. O le ni irora diẹ tabi ọgbẹ ni aaye ibiti a ti fi abẹrẹ sii, ṣugbọn ọpọlọpọ awọn aami aisan lọ ni kiakia.
Ko si eewu lati ni idanwo itọ.
Kini awọn abajade tumọ si?
Ti o ba danwo ṣaaju ki o to bẹrẹ itọju kan, idanwo naa le fihan boya oogun yoo ṣeeṣe ki o munadoko ati / tabi ti o ba wa ninu eewu fun awọn ipa ti o lewu. Diẹ ninu awọn idanwo, gẹgẹbi awọn ti o wa fun awọn oogun kan ti o tọju warapa ati HIV, le fihan boya o wa ninu eewu fun awọn ipa ẹgbẹ ti o halẹ mọ ẹmi. Ti o ba ri bẹ, olupese rẹ yoo gbiyanju lati wa itọju miiran.
Awọn idanwo ti o ṣẹlẹ ṣaaju ati nigba ti o wa lori itọju le ṣe iranlọwọ fun olupese ilera rẹ lati mọ iwọn lilo to tọ.
Ti o ba ni awọn ibeere nipa awọn abajade rẹ, sọrọ si olupese iṣẹ ilera rẹ.
Kọ ẹkọ diẹ sii nipa awọn idanwo yàrá, awọn sakani itọkasi, ati oye awọn abajade.
Njẹ ohunkohun miiran ti Mo nilo lati mọ nipa idanwo oogun-oogun?
Ayẹwo Pharmacogenetic nikan lo lati wa idahun eniyan si oogun kan pato. Kii ṣe nkan kanna bi idanwo ẹda. Ọpọlọpọ awọn idanwo jiini ni a lo lati ṣe iranlọwọ iwadii awọn aisan tabi eewu ti o le ni arun, ṣe idanimọ ibatan ibatan ẹbi, tabi ṣe idanimọ ẹnikan ninu iwadii ọdaràn.
Awọn itọkasi
- Hefti E, Blanco J. Documenting Pharmacogenomic Testing with Awọn koodu Awọn ilana Terminology (CPT) lọwọlọwọ, Atunwo ti Awọn iṣe Tẹhin ati Lọwọlọwọ. J AHIMA [Intanẹẹti]. 2016 Jan [toka si 2018 Jun 1]; 87 (1): 56–9. Wa lati: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998735
- Awọn idanwo Lab lori Ayelujara [Intanẹẹti]. Washington DC: Ẹgbẹ Amẹrika fun Kemistri Ile-iwosan; c2001–2018. Awọn idanwo Pharmacogenetic; [imudojuiwọn 2018 Jun 1; toka si 2018 Jun 1]; [nipa iboju 2]. Wa lati: https://labtestsonline.org/tests/pharmacogenetic-tests
- Awọn idanwo Lab lori Ayelujara [Intanẹẹti]. Washington DC: Ẹgbẹ Amẹrika fun Kemistri Ile-iwosan; c2001–2018. Aye ti Idanwo Jiini; [imudojuiwọn 2017 Nov 6; toka si 2018 Jun 1]; [nipa iboju 2]. Wa lati: https://labtestsonline.org/articles/genetic-testing?start=4
- Ile-iwosan Mayo: Ile-iṣẹ fun Oogun Ti Ẹtọ [Intanẹẹti]. Foundation Mayo fun Ẹkọ Iṣoogun ati Iwadi; c1998–2018. Idanwo Oogun-Gene; [toka si 2018 Jun 1]; [nipa iboju 3]. Wa lati: http://mayoresearch.mayo.edu/center-for-individualized-medicine/drug-gene-testing.asp
- Ile-iwosan Mayo: Ile-iṣẹ fun Oogun Ti Ẹtọ [Intanẹẹti]. Foundation Mayo fun Ẹkọ Iṣoogun ati Iwadi; c1998–2018. CYP2D6 / Tamoxifen Pharmacogenomic Lab igbeyewo; [toka si 2018 Jun 1]; [nipa iboju 5].Wa lati: http://mayoresearch.mayo.edu/center-for-individualized-medicine/cyp2d6-tamoxifen.asp
- Ile-iwosan Mayo: Ile-iṣẹ fun Oogun Ti Ẹtọ [Intanẹẹti]. Foundation Mayo fun Ẹkọ Iṣoogun ati Iwadi; c1998–2018. HLA-B * 1502 / Carbamazepine Pharmacogenomic Lab igbeyewo; [toka si 2018 Jun 1]; [nipa iboju 4]. Wa lati: http://mayoresearch.mayo.edu/center-for-individualized-medicine/hlab1502-carbamazephine.asp
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- Ile-iwosan Mayo: Awọn ile-iwosan Iṣoogun Mayo [Intanẹẹti]. Foundation Mayo fun Ẹkọ Iṣoogun ati Iwadi; c1995–2018. Idanwo Idanwo: PGXFP: Igbimọ Ile-iwosan Pharmacogenomics ti a dojukọ: Apejuwe; [toka si 2018 Jun 1]; [nipa iboju 3]. Wa lati: https://www.mayomedicallaboratories.com/test-catalog/Specimen/65566
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- Okan Orilẹ-ede, Ẹdọfóró, ati Ẹjẹ Ẹjẹ [Intanẹẹti]. Bethesda (MD): Ẹka Ilera ti U.S. ati Awọn Iṣẹ Eda Eniyan; Awọn idanwo ẹjẹ; [toka si 2018 Jun 1]; [nipa iboju 3]. Wa lati: https://www.nhlbi.nih.gov/health-topics/blood-tests
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Alaye lori aaye yii ko yẹ ki o lo bi aropo fun itọju iṣoogun ọjọgbọn tabi imọran. Kan si olupese ilera kan ti o ba ni awọn ibeere nipa ilera rẹ.